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  • Title: [Effects of opioid analgesics on potential-gated ion channels in the pond snail neurons].
    Author: Vislobokov AI, Savos'kin AL.
    Journal: Eksp Klin Farmakol; 2000; 63(4):7-12. PubMed ID: 11022297.
    Abstract:
    The effects of opioid analgesics morphine, promedol, tramadol, and butorphanol on the transmembrane calcium, sodium, and potassium (fast and slow) ion currents in pond snail (Lymnaea stagnalis) neurons were studied by intracellular dialysis and membrane potential (voltage-clamp) measurements. It was established that all these drugs produce a dose-dependent reversible inhibition of the ion currents (sodium calcium potassium) and reduce nonspecific leak currents, thus producing a stabilizing action upon the sample membrane. The current-inhibiting effect of morphine was not eliminated by naloxone (500 microM); moreover, the latter drug significantly inhibited the ion currents as well.
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