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  • Title: [Study on polymorphism of MICA exon 5 microsatellite in Shanghai Han population].
    Author: Guo Z, Xu L, Fan L, Ge Y, Yao F, Yang J.
    Journal: Zhonghua Yi Xue Yi Chuan Xue Za Zhi; 2000 Oct; 17(5):332-5. PubMed ID: 11024213.
    Abstract:
    OBJECTIVE: To investigate the polymorphism distribution of MICA gene exon 5 microsatellite in Shanghai Han population and study the relationship of MICA gene and its closely linked gene HLA B. METHODS: The microsatellite polymorphism of MICA exon 5 in 175 unrelated healthy individuals were investigated using PCR-heteroduplex analysis. RESULTS: (1)There are 5 alleles of the microsatellite polymorphism in exon 5 of the MICA gene in Shanghai Han population, the gene frequency of MICA*A5 is the highest(39.14%), the next is MICA*A5.1(22.29%). (2)There is strong linkage disequilibrium between the HLA-B and MICA STR loci, e.g. MICA*A5 and HLA-B15, MICA*A4 and HLA-B27. CONCLUSION: The polymorphism distribution of MICA gene and the linkage disequilibrium between MICA and HLA-B have deviations in different ethnic groups.
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