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  • Title: [Alternative splicing of RHAMM gene in chinese gastric cancers and its in vitro regulation].
    Author: Li H, Guo L, Li J, Liu N, Liu J.
    Journal: Zhonghua Yi Xue Yi Chuan Xue Za Zhi; 2000 Oct; 17(5):343-7. PubMed ID: 11024216.
    Abstract:
    OBJECTIVE: To identify the receptor of hyaluronic acid mediated motility (RHAMM), expression pattern(s) in the gastric mucosa with various lesions and to elucidate the effect of hyaluronic acid(HA) on in vitro RHAMM expression. METHODS: Immunocytochemical staining and Western blot hybridization were performed to check the expression patterns and locations of RHAMM molecules in the noncancerous, preneoplastic and malignant gastric specimens. RHAMM expression of the two stomach cancer cell lines cultured conventionally or under the conditions with gelatin or HA supplementation was evaluated as well. RESULTS: Mr 93000-95000 intracellular RHAMM, so-called IHABP, proteins were detected in 17% noncancerous mucosa. The multiple spectrums and increased frequencies of RHAMM expression could be observed in the majority of the cancer cases with both intracellular and cell surface labeling. HA but not gelatin could promote membrane type RHAMM (mRHAMM) expression of stomach cancer cells in a dose associated pattern. CONCLUSION: The expression of mRHAMM variants is closely associated with tumor progression, which may be promoted and modulated by HA.
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