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  • Title: Terbogrel, a dual-acting agent for thromboxane receptor antagonism and thromboxane synthase inhibition.
    Author: Michaux C, Norberg B, Dogné JM, Durant F, Masereel B, Delarge J, Wouters J.
    Journal: Acta Crystallogr C; 2000 Oct; 56 ( Pt 10)():1265-6. PubMed ID: 11025320.
    Abstract:
    Terbogrel, (E)-6-[4-(3-tert-butyl-2-cyanoguanidino)phenyl]-6-(3-pyridyl)hex-5 -enoic acid, C(23)H(27)N(5)O(2), a mixed thromboxane A(2) receptor antagonist and thromboxane A(2) synthase inhibitor, shows a hairpin-like conformation stabilized by an intramolecular hydrogen bond. A structural feature characteristic of the thromboxane A(2) synthase inhibitor mode is observed: a distance of 8.4257 (19) A between the pyridine N atom and the carboxyl group.
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