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  • Title: NMDA channel blockers: memantine and amino-aklylcyclohexanes--in vivo characterization.
    Author: Danysz W, Parsons CG, Quack G.
    Journal: Amino Acids; 2000; 19(1):167-72. PubMed ID: 11026485.
    Abstract:
    The previous overviews provided the basis for better therapeutic efficacy/tolerability of low to moderate affinity NMDA channel blockers. This prediction finds support in in vitro studies comparing protective and plasticity impairing effects (therapeutic vs. side-effect) of memantine and (+)MK-801. In fact it turned out that memantine had a far better therapeutic index. But can it be confirmed in the in vivo situation?
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