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  • Title: High level, tissue-specific expression of a modified calcitonin/calcitonin gene-related peptide promoter in a human medullary thyroid carcinoma cell line.
    Author: Messina M, Yu DM, Learoyd DL, Both GW, Molloy PL, Robinson BG.
    Journal: Mol Cell Endocrinol; 2000 Jun; 164(1-2):219-24. PubMed ID: 11026573.
    Abstract:
    The efficient and high level expression of therapeutic genes in target cells is critical for effective gene therapy. We have developed a novel promoter by utilizing tandem repeats of a tissue-specific regulatory element from the calcitonin/calcitonin gene-related peptide (CT/CGRP) gene placed in close proximity to a basal promoter, thereby removing interstitial sequences. This promoter drives expression of reporter genes at much higher levels than the natural promoter while significantly improving specificity in thyroid C cells.
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