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  • Title: d-Aspartate in a prolactin-secreting clonal strain of rat pituitary tumor cells (GH(3)).
    Author: Long Z, Lee JA, Okamoto T, Nimura N, Imai K, Homma H.
    Journal: Biochem Biophys Res Commun; 2000 Oct 05; 276(3):1143-7. PubMed ID: 11027602.
    Abstract:
    d-Aspartate (d-Asp) is found in prolactin (PRL)-containing cells of the rat anterior pituitary gland [Lee et al., Brain Res. 838, 193-199, 1999]. In order to determine whether d-Asp is actually produced by the anterior pituitary gland and whether it plays a physiological role in PRL function, a PRL-secreting clonal strain of rat pituitary tumor cells (GH(3)) was employed in this study. HPLC analysis and immunocytochemical staining detected the presence and synthesis of d-Asp in the cytoplasm of these cells. In addition, thyrotropin-releasing hormone-stimulated PRL secretion was increased in a dose-dependent fashion by d-Asp from these cells. These results suggest that the anterior pituitary gland synthesizes d-Asp and that d-Asp acts as a messenger in this gland.
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