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  • Title: Molluscicidal activity of 2-hydroxy-3-alkyl-1,4-naphthoquinones and derivatives.
    Author: dos Santos AF, Ferraz PA, Pinto AV, Pinto M do C, Goulart MO, Sant'Ana AE.
    Journal: Int J Parasitol; 2000 Oct; 30(11):1199-202. PubMed ID: 11027788.
    Abstract:
    In the search for new molluscicidal agents we tested the activity of lapachol and other 2-hydroxy-3-alkylnaphthoquinones possessing nitrogenated alkyl chains, against the snail Biomphalaria glabrata. Lapachol, isolapachol and nor-lapachol showed strong molluscicidal activity against the adult snail (LD(90)<10 ppm) and significant toxicity against snail egg masses (LD(90)<0.2 ppm). As lapachol is easily extracted, and the derivatives can be synthesised without any difficulty, large-scale synthesis and field tests can be conducted, with a view to large-scale molluscicidal programs.
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