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  • Title: Role of TnrA in nitrogen source-dependent repression of Bacillus subtilis glutamate synthase gene expression.
    Author: Belitsky BR, Wray LV, Fisher SH, Bohannon DE, Sonenshein AL.
    Journal: J Bacteriol; 2000 Nov; 182(21):5939-47. PubMed ID: 11029411.
    Abstract:
    Synthesis of glutamate, the cell's major donor of nitrogen groups and principal anion, occupies a significant fraction of bacterial metabolism. In Bacillus subtilis, the gltAB operon, encoding glutamate synthase, requires a specific positive regulator, GltC, for its expression. In addition, the gltAB operon was shown to be repressed by TnrA, a regulator of several other genes of nitrogen metabolism and active under conditions of ammonium (nitrogen) limitation. TnrA was found to bind directly to a site immediately downstream of the gltAB promoter. As is true for other genes, the activity of TnrA at the gltAB promoter was antagonized by glutamine synthetase under certain growth conditions.
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