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  • Title: Immunophenotypical characterization of the lymphocyte infiltrate in caprine pulmonary tuberculosis.
    Author: Seva J, Hernández D, Bernabé A, Pallarés FJ, Navarro JA.
    Journal: J Comp Pathol; 2000; 123(2-3):96-103. PubMed ID: 11032661.
    Abstract:
    A study was made of the immunophenotype of the lymphocytes associated with natural caprine pulmonary tuberculosis at four stages of the disease. Regardless of the stage, CD4(+)and CD8(+)T lymphocytes predominated in lung and mediastinal lymph node lesions, but gamma/delta T and B (IgM(+)) cells were seen only rarely. At the primary complex stage, CD4(+)cells outnumbered CD8(+)cells. At the stage of generalized tuberculosis, however, and still more at the post-primary stage, CD8(+)cells outnumbered CD4(+)cells. At the final stage (tuberculous pneumonia), CD4(+)and CD8(+)cells were present in low but approximately equal numbers.
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