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  • Title: Transmission of Creutzfeldt-Jakob disease from man to the guinea pig.
    Author: Manuelidis EE.
    Journal: Science; 1975 Nov 07; 190(4214):571-2. PubMed ID: 1103289.
    Abstract:
    Intracerebral and intraperitoneal inoculation of two guinea pigs with biopsy material from a patient with Creutzfeldt-Jakob disease produced a similar fatal encephalopathy characterized by status spongiosus 422 and 512 days after inoculation. Serial transmission of this disease from guinea pig to guinea pig was achieved in subsequent passages.
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