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  • Title: [Acinar epithelium as a source for the formation of the human pancreatic islets in embryogeny].
    Author: Puzyrev AA.
    Journal: Tsitologiia; 1975 Oct; 17(10):1138-41. PubMed ID: 1103393.
    Abstract:
    By electron microscopy in the islets of Largenhans and acini of the pancreas of the human fetuses 4-7 months old acinar-islet (transitional) cells were revealed. The cytoplasm of some transitional elements contained zymogen and endocrine A-granules, while in others zymogen and endocrine B-granules were found. Acinar-islet cells differed by the structure of organelles and by the quantity of endocrine granules, which can be regarded as transformation of acinar cells into endocrine cells. A conclusion was drawn that during human pancreas embryogenesis the acinar epithelium is one of the sources of islet tissue formation.
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