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  • Title: Pre- and postsynaptic effects of eugenol and related compounds on Helix pomatia L. neurons.
    Author: Szabadics J, Erdélyi L.
    Journal: Acta Biol Hung; 2000; 51(2-4):265-73. PubMed ID: 11034151.
    Abstract:
    We showed how eugenol blocks the synaptic transmission and gave a possible interpretation how it inhibits the excitation-contraction coupling that several authors described previously. Eugenol acts both in the pre- and postsynaptic side of the neurons. It blocks the Ca2+-currents, decreases the membrane potential of the neurons, increases the inward resistance and decreases the GABA, ACh and glutamate evoked excitatory responses in submillimolar concentration.
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