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  • Title: Effect of surgical isolation of the hypothalamus on its neurotransmitter content.
    Author: Brownstein MJ, Palkovits M, Tappaz ML, Saavedra JM, Kizer JS.
    Journal: Brain Res; 1976 Nov 26; 117(2):287-95. PubMed ID: 11035.
    Abstract:
    The concentrations of norepinephrine, dopamine-beta-hydroxylase, dopamine, tyrosine hydroxylase, phenylethanolamine-N-methyltransferase, serotonin, tryptophan hydroxylase, histamine, glutamic acid decarboxylase, and choline acetyltransferase were determined in selected hypothalamic nuclei and in the median eminence after deafferentation of the medial basal hypothalamus. Norepinephrine and dopamine-beta-hydroxylase fell markedly while dopamine and tyrosine hydroxylase did not. Serotonin also decreased in all regions studied; histamine decreased in none. Choline acetyltransferase, phenylethanolamine-N-methyltransferase, and glutamic acid decarboxylase declined in some areas, but not in others.
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