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  • Title: Differential biosynthesis of polyunsaturated fatty acids by Tetrahymena supplemented with ergosterol.
    Author: Neville ME, Miin TC, Ferguson KA.
    Journal: Biochim Biophys Acta; 1979 Apr 27; 573(1):201-6. PubMed ID: 110351.
    Abstract:
    Tetrahymena grown with foreign sterols such as ergosterol incorporate them into cellular membranes at the expense of the native compound, tetrahymanol. It is shown that cells grown with ergosterol have a lessened capacity to produce the polyunsaturated linoleic and gamma-linolenic acids from [14C]oleic acid. However, the same cells have normal capacities to introduce double bonds at C-6 into linoleate, alpha-linolenate, or cis-vaccenate. Thus, a presumed 12-desaturase is inhibited in the presence of ergosterol, while desaturation at C-6 is unaffected.
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