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  • Title: Comparison of the complement fixation, indirect immunofluorescence, and indirect hemagglutination tests for malaria.
    Author: Wilson M, Fife EH, Mathews HM, Sulzer AJ.
    Journal: Am J Trop Med Hyg; 1975 Sep; 24(5):755-9. PubMed ID: 1103641.
    Abstract:
    The complement fixation (CF), indirect immunofluorescence (IIF), and indirect hemagglutination (IHA)tests for malaria were compared by using sera from U.S. citizens with either natural infections or heroin-associated, needle-induced infections. In natural Plasmodium vivax infections, the CF, IIF, and IHA tests apparently detect malarial antibodies equally efficiently for the first 2 months after the onset of symptoms, but the titers obtained by CF and IIF rapidly decline within a year, while the IHA titers remain elevated. In the sera from heroin addicts who developed needle-induced P. vivax infections, sensitivities of all three tests were decreased: the IIF and IHA tests each detected 83%, but the CF test detected only 57.1%. False-positive reactions with this group were very high for the CF (76.6%) and IHA (15.9%) tests, but only 2% for IIF.
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