These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Studies of thymus-derived and bone marrow-derived lymphocytes in renal transplant patients.
    Author: Thomas F, Owens L, Lee HM, Wolf JS, Thomas J, Mendez G, Volk M.
    Journal: Am Surg; 1975 Nov; 41(11):738-44. PubMed ID: 1103670.
    Abstract:
    Serial studies of levels and responsiveness of T and B lymphocytes were performed in human renal allograft recipients. Patients given prednisolone-azathioprine immunosuppression had only mild falls in levels and responsiveness of T cells. Patients given a quality controlled ATG preparation had marked and relatively selective falls in levels of T cells associated with a marked fall in T cell responsiveness as measured by PHA and Con-A responsiveness. In vivo correlates of this severe T cell deficiency suggest that T lymphocytes are central to acute allograft rejection and that acute severe T cell deficiency is not associated with risk of infectious complications above and beyond those seen in patients suppressed with prednisone-azathioprine alone. These studies suggest that ATG, produced under quality control conditions and having rather selective anti-T cell activity, is a useful adjunctive immunosuppressive agent for human renal transplantation.
    [Abstract] [Full Text] [Related] [New Search]