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  • Title: [Loss of heterozygosity in the 9p21 region as an inactivation mechanism of the p16 suppressor gene].
    Author: Maestro de las Casas ML, Sanz-Casla MT, del Barco V, Moreno J, Zanna I, Redondo E, Fernández C, Izquierdo L, Resel Estévez L.
    Journal: Arch Esp Urol; 2000 Sep; 53(7):603-9. PubMed ID: 11037653.
    Abstract:
    OBJECTIVE: To determine the loss of heterozygosity (LOH) on 9p21 (locus D9S1747) in patients with renal carcinoma by analysis of microsatellite polymorphisms. METHODS: 40 patients with sporadic renal cancer were studied. LOH on 9p21 was performed by analysis of microsatellite polymorphisms. RESULTS: 23.7% showed LOH on 9p21. No correlation was found between this genetic alteration and tumor features. CONCLUSIONS: LOH on 9p21 was found in 23.7% of the patients in this series. LOH was found in 26.9% of renal cell carcinomas, 25% of papillary carcinomas and 25% of Bellini duct carcinomas. LOH was not found in the other histological types.
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