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Title: Trypanosoma brucei: four tandemly linked genes for fatty acyl-CoA synthetases. Author: Jiang DW, Ingersoll R, Myler PJ, Englund PT. Journal: Exp Parasitol; 2000 Sep; 96(1):16-22. PubMed ID: 11038316. Abstract: We have cloned four acyl CoA synthetase (ACS) genes from Trypanosoma brucei strain 927. Each of these genes encodes a polypeptide about 78 kDa in size and all four contain the "ACS signature motif." Sequence alignments indicate that these proteins are 46%-95% identical in amino acid sequence. Interestingly, three of them share almost identical C-termini (about 215 amino acid residues). Southern blots suggest that these genes are present in a single copy, and Northern blots reveal that all four are expressed in both bloodstream and procyclic trypanosomes.[Abstract] [Full Text] [Related] [New Search]