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  • Title: [Detection of Epstein-Barr virus in lymphoproliferative diseases by in situ hybridization].
    Author: Xia C, Liu F, Sun Y.
    Journal: Zhonghua Zhong Liu Za Zhi; 1997 Jul; 19(4):267-9. PubMed ID: 11038755.
    Abstract:
    OBJECTIVE: To study the relationship between Epstein-Barr virus and various lymphoproliferative diseases in China. METHODS: Tissues from 214 patients with lymphoproliferative diseases were examined for the presence of Epstein-Barr virus (EBV) using in situ hybridization with EBV's LMP gene as probe. RESULTS: The positive rate of EBV in Hodgkin's disease(HD), Non-Hodgkin's Lymphoma(NHL), benign lymphoid proliferative disease(BLP) was 30.0%(15/50), 14.0%(18/129), 2.9%(1/35), respectively. Among NHL, EBV was detected in 28.1%(9/32) of high grade lymphoma (HNHL), 10.5%(9/84) of medium grade lymphoma(MNHL) and in none(0/9) of low grade lymphoma(LNHL). Significantly higher rates than that of BLP were observed in HD and HNHL. No significant differences in rates among patients with MNHL, LNHL and BLP. CONCLUSION: EBV may be involved in the pathogenesis of HD and HNHL, but not in MNHL and LNHL.
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