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  • Title: Gallotannins inhibit growth, water-insoluble glucan synthesis, and aggregation of mutans streptococci.
    Author: Wu-Yuan CD, Chen CY, Wu RT.
    Journal: J Dent Res; 1988 Jan; 67(1):51-5. PubMed ID: 11039045.
    Abstract:
    During screening for anti-plaque agents of plant origin, ethanolic extracts from Melaphis chinensis (Bell), the Chinese Nutgall, exhibited strong inhibition of glucosyltransferase (GTF), in vitro adherence and glucan-induced agglutination of Streptococcus mutans 3209 and S. sobrinus B13. More than 91% inhibition of water-insoluble glucan synthesis from sucrose by GTF was noted at a concentration as low as 7.8 micrograms/mL. Bactericidal effects on other mutans streptococci, S. salivarius, and Actinomyces viscosus were also evident. Through chemical fractionation and analyses, along with bioassays, the active components were identified as gallotannins.
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