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  • Title: Fatal invasive cerebral Absidia corymbifera infection following bone marrow transplantation.
    Author: Paterson PJ, Marshall SR, Shaw B, Kendra JR, Ethel M, Kibbler CC, Prentice HG, Potter M.
    Journal: Bone Marrow Transplant; 2000 Sep; 26(6):701-3. PubMed ID: 11041574.
    Abstract:
    A 56-year-old dairy farmer received a fully HLA matched unrelated donor marrow transplant for high risk CML in chronic phase. His early post-transplant course was complicated by a series of massive intracerebral bleeds and by sepsis related to a malignant otitis externa. The microbial pathogen isolated from ear swabs was found to be Absidia corymbifera, but CT scan at the time showed no intracerebral extension. Despite neutrophil engraftment and aggressive antifungal management he succumbed. Autopsy revealed invasion of Absidia into the brain from the ear. We speculate that colonisation by Absidia resulted from occupational exposure.
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