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  • Title: Fatal thrombotic thrombocytopenic purpura as a rare complication following allogeneic stem cell transplantation.
    Author: Chemnitz J, Fuchs M, Blau W, Hartmann P, Wickenhauser C, Scheid C, Schulz A, Diehl V, Söhngen D.
    Journal: Ann Hematol; 2000 Sep; 79(9):527-9. PubMed ID: 11043426.
    Abstract:
    Thrombotic thrombocytopenic purpura (TTP) is a rare disease which, together with hemolytic uremic syndrome, is subsumed under thrombotic microangiopathy. After stem cell transplantation (SCT), this syndrome represents a possibly fatal complication with a higher incidence in allogeneic SCT than in autologous SCT. Although plasmapheresis offers an encouraging treatment modality in classic TTP, this seems less effective in bone marrow transplant-associated microangiopathy. This is probably due to a different etiology. We present a case of transplant-associated TTP with a fatal outcome despite multiple courses of plasmapheresis.
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