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  • Title: p53 codon 72 polymorphism in vulval cancer and vulval intraepithelial neoplasia.
    Author: Rosenthal AN, Ryan A, Hopster D, Jacobs IJ.
    Journal: Br J Cancer; 2000 Nov; 83(10):1287-90. PubMed ID: 11044351.
    Abstract:
    p53 codon 72 polymorphism was analysed in UK women with human papillomavirus (HPV)-associated vulval intraepithelial neoplasia and vulval squamous cell carcinoma. Arginine homozygotes were significantly less common in either group compared with controls. We conclude that the arginine polymorphism may confer protection against the development of HPV-associated vulval neoplasia.
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