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  • Title: Toxoplasma gondii Hsp70 as a danger signal in toxoplasma gondii-infected mice.
    Author: Mun HS, Aosai F, Norose K, Chen M, Hata H, Tagawa YI, Iwakura Y, Byun DS, Yano A.
    Journal: Cell Stress Chaperones; 2000 Oct; 5(4):328-35. PubMed ID: 11048655.
    Abstract:
    Toxoplasma gondii Hsp70, T gondii Hsp30/bag1, and surface antigen 1 messenger RNAs were shown to be useful in analyzing stage conversion of T gondii between bradyzoites and tachyzoites. The high-level expression of T gondii Hsp70 was correlated with mortality in interferon-gamma knockout mice infected with T gondii. Tgondii Hsp70 inhibited the induction of nitric oxide release by peritoneal macrophages of T gondii-infected mice. These findings identify T gondii Hsp70 as a danger signal during lethal, acute T gondii infection.
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