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  • Title: Isolated pericardial effusion and transient abnormal myelopoiesis in a fetus with Down's syndrome.
    Author: Hirashima C, Eguchi Y, Kohmura Y, Minakami H, Sato I.
    Journal: J Obstet Gynaecol Res; 2000 Aug; 26(4):303-6. PubMed ID: 11049242.
    Abstract:
    Isolated pericardial effusion was detected in a fetus at 34 weeks of gestation. A male infant weighing 2,044 g was born by cesarean section because of a non-assuring fetal heart rate pattern at 35 weeks of gestation. Transient leukocytosis (36,100/microl) with 49% blast cells was seen in this neonate. The infant's karyotype was 47, XY + 21. The pericardial effusion disappeared after treatment with prednisolone at a dose of 2 mg/kg/day. Hypothyroidism was subsequently found. Thus, the subject patient with Down's syndrome developed isolated pericardial effusion, transient abnormal myelopoiesis (TAM), and hypothyroidism. Because more than 20% of the infants with TAM and Down's syndrome develop acute nonlymphocytic leukemia in early childhood, he is being closely observed.
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