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  • Title: Cytohesins and centaurins: mediators of PI 3-kinase-regulated Arf signaling.
    Author: Jackson TR, Kearns BG, Theibert AB.
    Journal: Trends Biochem Sci; 2000 Oct; 25(10):489-95. PubMed ID: 11050434.
    Abstract:
    Receptor-activated phosphoinositide (PI) 3-kinases produce PtdIns(3, 4,5)P(3) and its metabolite PtdIns(3,4)P(2) that function as second messengers in membrane recruitment and activation of target proteins. The cytohesin and centaurin protein families are potential targets for PtdIns(3,4,5)P(3) that also regulate and interact with Arf GTPases. Consequently, these families are poised to transduce PI 3-kinase activation into coordinated control of Arf-dependent pathways. Proposed downstream events in PI 3-kinase-regulated Arf cascades include modulation of vesicular trafficking and the actin cytoskeleton.
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