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  • Title: The regulation of L-type Ca2+ currents in rat cardiac myocytes.
    Author: Markevich NI, Korystova AF, Grichenko AS, Lankina DA, Kokoz YM.
    Journal: Membr Cell Biol; 2000; 14(1):109-27. PubMed ID: 11051087.
    Abstract:
    The regulation of L-type Ca2+ current in isolated rat cardiac cells was studied using the perforated patch-clamp technique. A dual effect of the cAMP-dependent phosphorylation activator, isoproterenol, at different holding potentials (V(h)) was shown. The currents increased at V(h) = -50 mV and decreased at V(h) = -30 mV. A dihydropyridine agonist, BAY K 8644, and isoproterenol had an additive effect on the activation of Ca2+ channels at holding potentials close to the resting potential. The additivity was disturbed at more positive V(h). The activating effect of BAY K 8644 did not virtually change in the presence of a protein kinase blocker, H8, and a phosphatase activator, acetylcholine. The results were interpreted within the framework of a two-site phosphorylation model with two independent pathways of Ca2+ current regulation.
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