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  • Title: Chronic multiple paraneoplastic syndromes.
    Author: Kleopa KA, Teener JW, Scherer SS, Galetta SL, Bird SJ.
    Journal: Muscle Nerve; 2000 Nov; 23(11):1767-72. PubMed ID: 11054759.
    Abstract:
    A patient presented with symptoms of limbic and brainstem encephalitis, motor and sensory neuronopathy, cerebellar dysfunction, and highly positive anti-Hu antibodies. He also harbored P/Q-type calcium channel antibodies and manifested the Lambert-Eaton myasthenic syndrome (LEMS). Small-cell lung cancer was found, and he received both antineoplastic therapy and intravenous immunoglobulin (IVIg). Remission of the malignancy was achieved. Although the anti-Hu-related manifestations improved after therapy, LEMS has persisted, leading to IVIg dependency.
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