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  • Title: Proteinuria as diagnostic marker after human kidney transplantation.
    Author: Boesken WH, Schmidt M, Jontofsohn R, Heinze V.
    Journal: Proc Eur Dial Transplant Assoc; 1975; 11():333-42. PubMed ID: 1105554.
    Abstract:
    Molecular weight analyses of urinary proteins in 34 patients following cadaveric kidney transplantation were performed by SDS-PAA-electrophoresis in order to diagnose transplant complications. A micromolecular 'tubular' proteinuria (mw 70-10,000) was found in all post-operative urines. Later on during clinically normal periods the patients exhibited an unphysiological proteinuria of mw 70-40,000. Recurrence of tubular proteinuria was associated with rejection episodes and acute kidney failure. Twelve patients developed a macromolecular glomerular proteinuria (mw greater than 60,000), caused by recurrent glomerulonephritis, glomerular rejection disease or renal vein thrombosis. Steroid treatment reduced the glomerular permeability for macromolecules above mw 65,000.
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