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  • Title: [A new model of translational control of gene expression in polycistron++ of AB5 entrerotoxin].
    Author: Cao C, Li P, Wang P, Li JZ, Shi CH, Ma QJ.
    Journal: Yi Chuan Xue Bao; 2000; 27(6):549-55. PubMed ID: 11057052.
    Abstract:
    The expression level of the B subunit gene of cholera toxin (ctx) and E. coli heat labile toxin (ltx) is five to seven times more than that of A subunit gene. In these studies, a 80 basepair translation regulation element was found located in the structure gene of A gene of both toxin operon which consists of three translation initiation region. Site-directed mutation of the initiation codon of TIR3 resulted in the 9 time decrease of the expression of the downstream cistron which was translational coupled with A gene. The results indicated that translation from the internal of A gene and translation coupling are responsible for the differential expression level of the A and B gene of AB5 enterotoxin.
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