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  • Title: Electroencephalogram silence ratio for early outcome prognosis in severe head trauma.
    Author: Theilen HJ, Ragaller M, Tschö U, May SA, Schackert G, Albrecht MD.
    Journal: Crit Care Med; 2000 Oct; 28(10):3522-9. PubMed ID: 11057811.
    Abstract:
    OBJECTIVE: To introduce the electroencephalogram silence-ratio (ESR) as a variable derived from mathematically processed electroencephalogram for early outcome prognosis in patients with severe head trauma and to comparatively assess sensitivity, specificity and predictive value vs. somatosensory evoked potentials and brainstem auditory evoked potentials. DESIGN: Prospective, interventional study. SETTING: Intensive care unit of a university hospital. PATIENTS: A total of 32 adults with severe acute head trauma (Glasgow Coma Scale score < or = 8). METHODS AND MAIN RESULTS: In all patients, electroencephalographic recording was continuously performed by frontomastoid electrode montage for 24-96 hrs after admission to the ICU. The data were subsequently computed by fast Fourier analysis and the ESR (intervals of suppression as periods >240 msecs during which the electroencephalographic voltage did not exceed 5 microV) was displayed and recorded on a computer for further evaluation. Somatosensory evoked potentials and brainstem auditory evoked potentials were elicited during the first 2 days after admission. Outcome evaluation was performed 6 months after trauma using the Glasgow Outcome Scale and the Rappaport Disability Rating Scale. After careful artifact exclusion, the ESR depicted the highest sensitivity, specificity, and positive predictive value compared with evoked potentials. Even a highly significant correlation between outcome and ESR was found (p < .0001). CONCLUSION: The ESR is a valuable variable showing a high reliability with respect to outcome prediction in severe head trauma with a higher predictive value than short latency somatosensory evoked potentials. Evidence exists that the ESR provides at least partial information regarding adequate cerebral oxygen delivery.
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