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  • Title: Inhibitors of aminoacyl-tRNA synthetases as novel anti-infectives.
    Author: Tao J, Schimmel P.
    Journal: Expert Opin Investig Drugs; 2000 Aug; 9(8):1767-75. PubMed ID: 11060775.
    Abstract:
    Resistance to existing antibiotics has emerged as a major problem in healthcare. Novel antibiotics for which bacteria have not yet acquired resistance need to be developed to combat drug-resistant pathogens. Aminoacyl-tRNA synthetases are leading targets for novel anti-infectives. The validation of aminoacyl-tRNA synthetases as drug targets for anti-infectives has been established in an animal system. Using several conceptually distinct approaches, new inhibitors of synthetases have been developed as drug prototypes.
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