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  • Title: Metronidazole and albendazole susceptibility of 11 clinical isolates of Giardia duodenalis from France.
    Author: Lemée V, Zaharia I, Nevez G, Rabodonirina M, Brasseur P, Ballet JJ, Favennec L.
    Journal: J Antimicrob Chemother; 2000 Nov; 46(5):819-21. PubMed ID: 11062206.
    Abstract:
    The metronidazole and albendazole susceptibility of 11 clinical isolates of Giardia duodenalis from France was determined using a neonatal mouse model and compared with the outcome in patients after standard metronidazole therapy (0.75 g/day for 5 days). All isolates found to be clinically resistant to metronidazole (4/11) exhibited an ID50 > 120 mg/kg in the mouse model. This therefore appears to be a suitable animal model in which to explore drug failures in human giardiasis.
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