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  • Title: Cutaneous Rosai-Dorfman disease--a pathologic review of 2 cases.
    Author: Chuah KL, Tan PH, Hwang SG, Ong BH.
    Journal: Singapore Med J; 2000 Mar; 41(3):122-5. PubMed ID: 11063196.
    Abstract:
    Rosai-Dorfman disease, also known as sinus histiocytosis with massive lymphadenopathy, is a rare but distinct clinicopathologic entity characterised histologically by a benign s histiocytic proliferation. Isolated involvement of extranodal sites without concomitant nodal disease is rare. We describe the pathological features of 2 cases of Rosai-Dorfman disease that were clinically confined to the skin. In both male adult Chinese patients, proliferation of histiocytes was accompanied by S-100 protein expression demonstrated immunohistochemically within the histiocytes. The pathology of Rosai-Dorfman disease and its microscopic differential diagnoses are discussed.
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