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  • Title: The dynamics of resting and postural tremor in Parkinson's disease.
    Author: Vaillancourt DE, Newell KM.
    Journal: Clin Neurophysiol; 2000 Nov; 111(11):2046-56. PubMed ID: 11068241.
    Abstract:
    OBJECTIVE: The study examines the time and frequency structure of Parkinson's disease tremor in patients that exhibit no clinical signs of tremor. METHODS: Eight mild to moderate Parkinson's disease and 8 matched control subjects maintained their limb in a constant position (30 s) under a postural finger, postural hand and resting tremor condition. Finger acceleration from the middle phalange, electromyographic (EMG) activity from extensor digitorum communis and flexor digitorum superficialis (FDS) were recorded. RESULTS: The data confirmed that there were no differences in the amount of limb motion and the modal frequency was around 9 Hz for each subject group. The time-dependent organization of tremor was more regular (lower approximate entropy [ApEn]) in Parkinson's disease. Both time and frequency analyses between the acceleration and extensor EMG signals demonstrate a reduction in the 20-25 Hz tremor component and an increase in the 8-12 Hz region of tremor. CONCLUSIONS: The results are discussed in relation to the proposal that increased regularity results from an increase in motor unit synchronization at 8-12 Hz and a reduction in the amplitude of the 20-25 Hz tremor component. The time and frequency structure of tremor may be useful in assessing individuals with Parkinson's disease.
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