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  • Title: [Neurosurgical treatment for dopamine-induced dyskinesias in Parkinson's disease patients].
    Author: Sugiyama K, Yokoyama T, Namba H.
    Journal: Nihon Rinsho; 2000 Oct; 58(10):2115-9. PubMed ID: 11068457.
    Abstract:
    The effects of current neurosurgical interventions for levodopa-induced dyskiensias (DID) in Parkinson's disease are reviewed. Thalamotomy has been reported to be effective for DID when the lesions include Vo or CM-Pf nucleus, while thalamic deep brain stimulation(DBS) is less effective than thalamotomy. Both pallidotomy and pallidal DBS are probably the most effective neurosurgical treatment for DID, because they significantly improve all of the DID, including off-period dystonia, without reduction of levodopa dosage. Subthalamic DBS has no direct therapeutic effects on DID, but substantially can improve DID as a result of decreased levodopa dosage. The effects of cerebral transplantation on DID remain undefined. More researches are expected to clarify the pathophysiology of DID.
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