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  • Title: Livedoid vasculopathy associated with heterozygous protein C deficiency.
    Author: Boyvat A, Kundakçi N, Babikir MO, Gürgey E.
    Journal: Br J Dermatol; 2000 Oct; 143(4):840-2. PubMed ID: 11069468.
    Abstract:
    Livedoid vasculopathy is characterized by recurrent painful ulceration of the feet, ankles and legs that heals with residual white atrophic scars. For many years, livedoid vasculopathy has been considered to be a primary vasculitic process. Recently, however, there has been a trend towards considering livedoid vasculopathy as an occlusive vasculopathy due to a hypercoagulable state. Livedoid vasculopathy (under the designation livedo vasculitis) was first reported to be associated with protein C deficiency in 1992. We describe an additional patient with livedoid vasculopathy associated with heterozygous protein C deficiency. This second reported case suggests that protein C deficiency may be one cause of the hypercoagulable condition in these patients and demonstrates the necessity for further investigation of thrombogenic factors underlying the disease.
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