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  • Title: Differential effects of hypothalamic deafferentation upon luteinizing hormone-releasing hormone in the median eminence and organum vasculosum of the lamina terminalis.
    Author: Weiner RI, Pattou E, Kerdelhue B, Kordon C.
    Journal: Endocrinology; 1975 Dec; 97(6):1597-600. PubMed ID: 1107018.
    Abstract:
    Complete deafferentation of the medial basal hypothalamus (MBH) was performed in male rats to ascertain the location of the cell bodies of nerve terminals containing luteinizing hormone-releasing hormone (LH-RH) in the external layer of the median eminence and the organum vasculosum of the lamina terminalis (OVLT). Radioimmunoassayable LH-RH in the MBH decreased to one-fourth of the control value 10 days after complete deafferentation, whereas, no change was observed in an area coextensive with the OVLT. Immunohistochemical staining of LH-RH appeared less intense within the median eminence of deafferented animals but was normal in the OVLT. These results suggest that the cell bodies of neurons producing LH-RH found in terminals in the OVLT lie outside the MBH. The possible explanations for the decreased LH-RH content in the median eminence are discussed.
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