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  • Title: Lytic growth of human herpesvirus 8: morphological aspects.
    Author: Tinari A, Monini P, Marchetti M, Ammendolia MG, Leone P, Ensoli B, Superti F.
    Journal: Ultrastruct Pathol; 2000; 24(5):301-10. PubMed ID: 11071568.
    Abstract:
    The human herpesvirus 8 (HHV-8), also known as Kaposi's sarcoma-associated herpesvirus, is a gamma herpesvirus associated with AIDS-related body cavity-based lymphomas (BCBL), also called primary effusion lymphomas (PEL). These are a rare form of non-Hodgkin lymphomas in which HHV-8 is present, often associated with Epstein-Barr virus (EBV) infection. HHV-8 is also present in a latent state or in a state of low-level persistence in different primary effusion lymphoma-derived cell lines, such BCBL-1 cells, that lack EBV infection. This cell line was induced to produce mature virions by treatment with 12-O-tetradecanoyl phorbol-13-acetate (TPA) and the characteristic ultrastructural features of HHV-8 lytic replication were identified and compared to those of the other members of Herpesviridae family.
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