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  • Title: Cloning and initial analysis of the human multidrug resistance-related MVP/LRP gene promoter.
    Author: Lange C, Walther W, Schwabe H, Stein U.
    Journal: Biochem Biophys Res Commun; 2000 Nov 11; 278(1):125-33. PubMed ID: 11071864.
    Abstract:
    The lung resistance-related protein (LRP) was identified as the human major vault protein (MVP), and is overexpressed in various multidrug-resistant cancer cell lines and clinical samples. We characterized DNA sequences upstream to the transcription initiation site of the MVP gene in the human non-small cell lung cancer cell line SW-1573. A 1.9-kb and a shortened 0.7-kb fragment of the 5'-upstream genomic region show strong promoter activity in chloramphenicol acetyltransferase (CAT) reporter assays. The promoter is TATA-less and contains an inverted CCAAT-box and a Sp1 site located near to a p53 binding motif. An alternative 3'-splice site of intron 1 results in a splicing variant within the 5'-untranslated region of MVP mRNA.
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