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  • Title: Time to reconstitution: purified Fab antivenom vs. unpurified IgG antivenom.
    Author: Hill RE, Bogdan GM, Dart RC.
    Journal: Toxicon; 2001 May; 39(5):729-31. PubMed ID: 11072054.
    Abstract:
    We conducted prospective, randomized analytical and observational trials to assess reconstitution times of two lyophilized crotaline snake antivenoms, Antivenin (Crotalidae) Polyvalent [Wyeth-Ayerst] (ACP) and affinity-purified, mixed monospecific crotalid antivenom ovine Fab (CroTAb) (Fab antivenom). The analytical experiment indicated Fab antivenom and ACP reached their maximum protein concentration at 25 and 45min, respectively. In the observational experiment, Fab antivenom (median 40min) had a shorter reconstitution time than ACP (>90min, p<0.008).
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