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  • Title: Response to LH-RH and HCG in two brothers with the Reifenstein syndrome.
    Author: Flatau E, Josefsberg Z, Prager-Lewin R, Markman-Halabe E, Kaufman H, Laron Z.
    Journal: Helv Paediatr Acta; 1976 Jan; 30(4-5):377-83. PubMed ID: 1107277.
    Abstract:
    Two brothers with Reifenstein syndrome underwent LH-RH and HCG tests at various ages ranging from 13 to 17 years. We found that at age 13 the plasma LH and FSH response to one LH-RH injection was normal. After the age of 14, the basal plasma concentration of LH and FSH and their response to LH-RH became elevated. Concomitantly the plasma testosterone levels rose to abnormal levels. These findings are compatible with progressive development of primary gonadal dysfunction and with peripheral insensitivity to testosterone.
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