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  • Title: Involvement of tyrosine hydroxylase up regulation in dexamethasone-induced hypertension of rats.
    Author: Kumai T, Asoh K, Tateishi T, Tanaka M, Watanabe M, Shimizu H, Kobayashi S.
    Journal: Life Sci; 2000 Sep 08; 67(16):1993-9. PubMed ID: 11072875.
    Abstract:
    We investigated the effect of dexamethasone (DEX) on tyrosine hydroxylase (TH) mRNA level, and TH activity and catecholamine levels in the adrenal medulla of the rat. DEX (1 mg/kg/day, s.c.) was administered for 2 days, and a control group was given corn oil. DEX significantly increased systolic blood pressure. TH mRNA level, TH activity, epinephrine level, and norepinephrine level in the adrenal medulla of DEX-treated rats were significantly higher than those of control rats. Also, epinephrine and norepinephrine levels in plasma were significantly higher in DEX-treated rats than in controls. alpha-Methyl-p-tyrosine prevented the DEX-induced blood pressure increase. These results suggest that the catecholamine synthetic pathway may be involved in DEX-induced hypertension.
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