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  • Title: Nonhepatosplenic gamma delta T-cell lymphoma with initial testicular compromise.
    Author: Scolnik MP, Burgos RA, Paz A, Weinreiter M, del Carmen Ardaiz M, Bare P, Hanza MC, de Dios Soler MA, Narbaitz MI, Palacios MF, Sasot A, Huberman A, de Bracco MM.
    Journal: Am J Hematol; 2000 Nov; 65(3):260-2. PubMed ID: 11074546.
    Abstract:
    We report here a case of nonhepatosplenic gammadelta T-cell lymphoma with undescribed initial localization in testis, without hepatosplenomegaly or adenopathies, and subsequent development in the maxillary sinus. The maxillar mass biopsy revealed a T-cell infiltration, and its immunologic characterization by flow cytometry showed a gammadelta T-cell phenotype (CD45+, CD3+, CD2+, TCR gammadelta+), without expression of CD7, CD5, CD1a, TdT, CD4, CD8, TCR alphabeta, or NK antigens (CD16, CD56, and CD57). Clonal gamma-chain gene rearrangement by polymerase chain reaction (PCR) was detected in testicular and maxillar biopsies. Epstein-Barr virus type 1 (EBV) sequences were detected by molecular biology in the biopsy material, suggesting that this oncogenic virus may play a role in the genesis of the clonal expansion of gammadelta T-cells. The patient was initially treated with standard chemotherapeutic protocols, with poor response and aggressive course.
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