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  • Title: [Mediastinal space-occupying lesion of uncertain histology: difficulties of differential diagnosis].
    Author: Grundmann J, Wolff T.
    Journal: Dtsch Med Wochenschr; 2000 Oct 13; 125(41):1227-31. PubMed ID: 11076261.
    Abstract:
    HISTORY AND ADMISSION FINDINGS: A 78-year-old woman had, for the previous 4 months, been aware of an easily moveable tumour in the jugular region. She had been feeling well except for general fatigue. Physical examination revealed a mass in the jugular region, a little over 2 cm in diameter. INVESTIGATIONS: Routine laboratory tests were normal, except for a raised erythrocyte sedimentation rate. After ultrasound, scintigraphy and computed tomography, a biopsy was performed. Histologically it was suspicious of a centroblastic centrocytic non-Hodgkin lymphoma, but further pathological investigation established the diagnosis of a malignant thymoma. TREATMENT AND COURSE: The tumour was resected and histological examination confirmed a malignant thymoma with infiltration of surrounding tissues. Radiotherapy was subsequently undertaken. CONCLUSION: Even though its evidence is low, a malignant thymoma or benign thymic tumour should be included in the differential diagnosis of a space-occupying mediastinal mass of unclear histology.
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