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  • Title: [Comparison of dinitrate isosorbide retard forms in ischemic heart disease patients with stable effort angina].
    Author: Lupanov VP, Alekseeva IA, Vasil'eva NN, Komar OA, Romasiuk SS, Naumov VG.
    Journal: Ter Arkh; 2000; 72(9):33-6. PubMed ID: 11076413.
    Abstract:
    AIM: To compare antianginal and anti-ischemic efficiency and tolerance of two forms of isosorbide dinitrate--cardiket-retard 120 mg and cardiket-retard 40 mg in IHD patients with stable effort angina. MATERIAL AND METHODS: The study included 18 IHD patients with stable angina of functional class II (5 patients) and III (13 patients). The trial was open cross-over. The treatment with both the forms lasted 1 month. Frequency of anginal attacks and exercise tolerance by veloergometry data were assessed. RESULTS: A significant decrease in the number of anginal attacks and greater exercise tolerance was recorded in cardiket 120 mg intake once a day. Both forms were well tolerated, serious side effects were absent. CONCLUSION: Comparison of the two isosorbide dinitrate dosage forms--cardiket 120 mg once a day and cardiket 40 mg 3 times a day--showed that the former is superior by clinical efficiency.
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