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  • Title: Proximal-distal leg development in Drosophila requires the apterous gene and the Lim1 homologue dlim1.
    Author: Pueyo JI, Galindo MI, Bishop SA, Couso JP.
    Journal: Development; 2000 Dec; 127(24):5391-402. PubMed ID: 11076760.
    Abstract:
    Proximal-distal leg development in Drosophila involves a battery of genes expressed and required in specific proximal-distal (PD) domains of the appendage. Here we report the characterisation of a new gene of this type, dlim1, a member of the Lhx family of genes whose proteins contain two Lim domains and a homeodomain. We show that the Lhx gene apterous (ap) is also required for PD leg development, and we study the functional interactions between ap, dlim1 and other PD genes during leg development. Our results show that a regulatory network formed by ap and dlim1 plus the homeobox genes aristaless and Bar specifies distal leg cell fates in Drosophila.
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