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  • Title: Raising low levels of high-density lipoprotein cholesterol is an important target of therapy.
    Author: Boden WE, Pearson TA.
    Journal: Am J Cardiol; 2000 Mar 01; 85(5):645-50, A10. PubMed ID: 11078282.
    Abstract:
    Recent clinical trials in patients with coronary heart disease indicate, for the very first time, that increasing low levels of high-density lipoprotein (HDL) cholesterol significantly reduces the cumulative occurrence of cardiovascular and cerebrovascular events in patients whose only lipid abnormality was low HDL with normal levels of low-density lipoprotein (LDL) cholesterol and triglycerides. These data provide a compelling scientific basis for a more targeted and segmental approach to managing patients with dyslipidemia, where decreasing elevated levels of LDL cholesterol and increasing low levels of HDL cholesterol should comprise dual targets of pharmacotherapy.
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