These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Nm23 and cathepsin D expression in laryngeal carcinomas.
    Author: Hadice Elif Pestereli, Gulay Ozbilim, Ozlem Elpek, Firat Fisenk, Esor Balkan.
    Journal: Adv Clin Path; 2000 Jul; 4(3):121-5. PubMed ID: 11080791.
    Abstract:
    AIMS: Cathepsin D and nm23 are two of the factors, investigated recently that have effects on invasion and metastasis of malign tumors. Cathepsin D is an aspartyl protease that plays a role in the invasion of tumor cells and is also found in stromal macrophages which are said to play a role in tumor invasiveness. The nm23 gene encodes nucleoside diphosphate (NDP) kinase that has a metastatic suppressor effect in some tumors but not in others. The aim of this study is to investigate expressions of nm23 and cathepsin D in laryngeal carcinomas. METHODS: Immunohistochemical method was used in 28 laryngeal carcinomas to demonstrate the expression of nm23 and cathepsin-D. MAIN RESULTS: Nearly all (26 of 28, 96 % ) carcinomas expressed nm23 protein without any difference between metastatic and non-metastatic carcinomas. 12 of 28 carcinomas (43 %) showed cathepsin D positivity regardless of T stage of the tumors. CONCLUSION: We found that nm23 expression and cathepsin D positivity had no effect on tumor progression in laryngeal carcinomas.
    [Abstract] [Full Text] [Related] [New Search]